Mast cells are pivotal effectors in immune responses, acting as both sentinels and mediators in allergic and inflammatory processes. Their ability to rapidly degranulate and release a myriad of ...

– AK006 inhibits IgE mediated mast cell activation and shows similar IgE inhibitory activity as remibrutinib – – AK006 also inhibits non-IgE mast cell activation pathways, including KIT-mediated ...

Known for their role in allergic reactions, mast cells have long been recognised as key players in our immune system. When they encounter allergens, they release chemicals that trigger typical allergy ...

The itching, redness and swelling of an allergic reaction are caused by mast cells—the vigilant first responders of the immune system that spring into action with histamine-filled granules in response ...

New understanding of a receptor key to allergic responses and anaphylaxis in conditions like asthma could offer a new treatment target for sufferers of a variety of conditions. This the promise of a ...

Indolent systemic mastocytosis (ISM) is a type of mastocytosis in which fewer clonal mast cells accumulate, thereby slowing the disease course and offering a better prognosis than other, more ...

This scanning electron microscopy image captures the moment where degranulating mast cells (pseudo-colored in sepia) attract and start to incorporate living neutrophils (pseudo-colored in cyan), ...

Among adults with evidence of systemic mast cell activation, bone marrow samples allowed for detection of 13 additional ...

For many patients with diverse and seemingly unrelated symptoms, obtaining an accurate diagnosis can take years of specialist visits and inconclusive tests. Mast cell activation syndrome, a disorder ...