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The work entitled " Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit" was published on Protein & Cell (published on Mar. 26 ...

Researchers have identified how cancer cells exploit ordinary metabolic processes to manipulate immune cells, supporting ...

The study investigates how the myocardial infarction (MI) microenvironment affects the reprogramming of cardiac fibroblasts (CFs) into cardiomyocytes (CMs), focusing on the role of macrophages and ...

When macrophages are actively fighting infections or responding to inflammation (as is the case with IBD), they activate a protein called hypoxia-inducible factor 1-alpha, or HIF-1α, to help them ...

Those animals were found to have increased macrophage density in the left ventricle and exhibited elevated levels of a factor called IL-10, which is known to contribute to fibroblast activation.

BUFFALO, N.Y. – Scientists have long known that white blood cells called macrophages accumulate in the lungs of people suffering from pulmonary fibrosis. What role macrophages play in developing the ...

The FDA has approved Gamifant as the first-ever treatment for macrophage activation syndrome in Still’s disease for adults and children who have an inadequate response or intolerance to ...

“The results suggest a potential mechanism, at the tissue level and involving macrophages, of how pulmonary fibrosis originates,” says the study’s first author Ying Xu, a PhD candidate in Zhao’s lab.