In turn, that weight gain and excess fat cells can contribute to leptin resistance. Leptin receptor deficiency is a rare ...

and two sets of obese mice that were leptin deficient but responsive to the hormone. These mice were fed either the low-calorie chow diet or the high-fat diet. The results were striking: “Obese mice ...

leptin-deficient ob/ob mice and intestine-specific leptin receptor isoform B-deficient mice. These data demonstrate that gastric leptin is upregulated in obese individuals. Results from high-fat ...

Palatin Technologies Inc. has obtained U.S. orphan drug designation for PL-7737 for leptin receptor (LEPR) deficiency, including obesity caused by this condition. BioWorld Science Regulatory Endocrine ...