As leptin is involved in numerous pathways, the effects of too little ... who have normal genes for leptin and its receptor, are leptin resistant. Despite extensive efforts in many laboratories ...

In "Leptin Receptor Neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss," researchers laid out the pathways, chemicals, neurons and brain ...

Because of these effects, it has been considered a plausible mechanism in the pathway leading from ... measured concentrations of leptin, its soluble leptin receptor and their ratio, known as ...

"Currently, the only FDA-approved treatment for obesity due to leptin receptor deficiency is a daily ... The Leptin-Melanocortin pathway in the hypothalamus plays a key role in regulating hunger ...

Results from high-fat diet mice showed that overexpression of gastric leptin that is linked to gut ‘5HT pathway’ occurred before the onset of obesity and expansion of fat mass. This may be ...

In a paper titled "Leptin Receptor Neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss," researchers lay out the pathways, chemicals ...

In “Leptin Receptor Neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss,” researchers laid out the pathways, chemicals, neurons and ...

The Leptin-Melanocortin pathway in the hypothalamus ... 3 Ayers KL, Glicksberg BS, Garfield AS, et al. Melanocortin 4 receptor pathway dysfunction in obesity: patient stratification aimed ...

More information: Marie Francois et al, Leptin receptor neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss, Metabolism (2024). DOI: 10.1016 ...