As the only child of a self-employed and largely self ... acids or lipid extracts of adipose tissue. In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy.

Fat accumulation can also be reduced by exercise, but extensive exercise and a large energy deficiency can lead to amenorrhea and hypoestrogenemia. Leptin is involved in energy homeostasis ...

Palatin Technologies Inc. has obtained U.S. orphan drug designation for PL-7737 for leptin receptor (LEPR) deficiency, including obesity caused by this condition. BioWorld Science Regulatory Endocrine ...

"Currently, the only FDA-approved treatment for obesity due to leptin receptor deficiency is a daily injection. PL7737's oral form could provide a more convenient and effective option for these ...

Obesity caused by LEPR deficiency is a rare genetic condition where mutations in the LEPR gene disrupt MC4R signaling. The Leptin-Melanocortin pathway in the hypothalamus plays a key role in ...