Journal References: Zuanning Yuan, Roxana Georgescu, Nina Y. Yao, Olga Yurieva, Michael E. O’Donnell, Huilin Li. Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis. Science ...

When copying the telomere, leading-strand DNA replication should copy the CCCTAA repeats to generate the TTAGGG repeat strand, while lagging-strand synthesis should do the opposite, making new ...

Box 1. Learning to Read Before Learning to Write The cost of sequencing has plummeted for the past 10–15 years at a pace that has outstripped Moore’s law. The cost of a human genome sequence ...

Normally for the lagging strand, DNA synthesis is unhindered, and the replisome starts synthesizing the last Okazaki fragments along the 3’ overhang that are later stitched together to prevent ...