Macrophages extend various cellular protrusions to capture and engulf bacteria. This study identifies dendrite-like pseudopods as a new type of branched protrusions formed by macrophages to enhance ...

(B) Macrophages are incubated with LPS (10 ng/mL) for 24h. Quantification of the pro-inflammatory response to LPS by RT-qPCR by measuring the relative expression of MCP-1 and IL-6 mRNAs.

Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling.

There are multiple types of macrophages, simplified as M0, M1, and M2. Of the three, M1 macrophages have the best tumor-fighting capacities and therefore have been used the most for cell therapies.

This macrophage switch was proven functionally relevant, as induction of macrophage-specific PDGFRβ-deficiency prevented their perivascular macrophage phenotype, impaired vessel maturation and ...

Amoedo-Leite, C., et al. (2024). Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support.