Discover how kinase inhibitors not only block proteins but also enhance their destruction, reshaping cancer treatment.

Precise Ca cycling through the sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle function. This cycling initially involves SR release of Ca via the ryanodine ...

Mitogen-activated protein kinase (MAPK) networks are essential for the transmission of extracellular signals into appropriate intracellular responses. Prototypical MAPK activation implements a ...

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems. These ...

The successful segregation of chromosomes in mitosis requires the timely coordination of cell cycle events to ensure the bipolar attachment of sister chromatids via their kinetochores to the mitotic ...

New research reveals that neurons release a little-understood extracellular kinase called VLK to strengthen synaptic ...

Arguably the most prominent target for drug development these days is kinase-directed therapy. Almost daily, there are news reports, articles, patents, and clinical trials describing how kinase ...

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...

Lei Wang, Jun Young Park, Fengming Liu, Kris M. Olesen, Shirui Hou, Jamy C. Peng, Jordan Infield, Anna C. Levesque, Yong-Dong Wang, Hongjian Jin, Yiping Fan, Patrick ...

Parkinson’s disease is the second most common neurodegenerative disorder, affecting more than ten million people worldwide. The breakdown of dopaminergic neurons in a brain region involved in movement ...

Researchers from The University of Texas at Dallas' Center for Advanced Pain Studies (CAPS) and their colleagues have made a ...