Setmelanotide reduced BMI by at least 5% at 16 weeks among 89% of children and adults with hypothalamic obesity, according to findings from a phase 2 trial published in The Lancet Diabetes ...

Shares of Rhythm Pharmaceuticals RYTM were up 36.6% yesterday after it reported positive top-line data from a phase II study evaluating the investigational oral melanocortin-4 receptor (MC4R) agonist, ...

An approval of Imcivree in hypothalamic obesity would be the first for this drug in an acquired form of obesity. It could also potentially become the first approved treatment for this specific ...

SAN FRANCISCO — In patients with acquired hypothalamic obesity, setmelanotide reduced BMI at 52 weeks compared with placebo, according to results of the TRANSCEND trial presented at ENDO 2025 ...

TOPLINE: Setmelanotide treatment over a 16-week period leads to a consistent decrease in both bodyweight and hunger among patients with hypothalamic obesity, according to the results of the first ...

Rhythm Pharmaceuticals' experimental drug helped patients with a rare form of obesity caused by brain damage cut weight in a small study, the drugmaker said on Monday, sending its shares 24% ...

Dec. 31, 2013 -- A Texas girl is fighting to stay healthy after complications from a brain tumor left her constantly hungry. Alexis Shapiro, 12, suffers from a rare condition called hypothalamic ...

Rhythm Pharmaceuticals is pursuing approval for its rare obesity disorder drug Imcivree in acquired hypothalamic obesity after it showed a 19.8% weight loss in a Phase III trial. The Boston-based ...

Rhythm estimates there are 5,000 to 8,000 people living with acquired hypothalamic obesity in Japan, 5,000 to 10,000 people living with acquired hypothalamic obesity in the U.S., and 3,500 to ...

Rhythm Pharmaceuticals (RYTM) announced the presentation of new, real-world data that showed four pediatric patients with acquired hypothalamic obesity or congenital hypothalamic obesity achieved ...

March 21, 2014 -- A Texas girl will get gastric bypass after the removal of a benign brain tumor left her always feeling hungry. Alexis Shapiro, 12, suffers from a rare condition called ...

Sucralose significantly increased hypothalamic blood flow compared to sucrose and water, suggesting that it may increase hunger signals in the brain. Participants reported feeling notably hungrier ...