‌Gastrointestinal perforation is when a hole develops in your gastrointestinal (GI) tract. This condition can easily have serious complications that could result in death. Early detection and ...

Results using the clone-censor-weight approach showed tocilizumab exposure was not associated with an increased risk for GI perforation (hazard ratio, 1.05; 95% CI, 0.30-1.65).

Using a maximally sensitive definition for GI perforation, the researchers identified 696 hospitalizations with perforation, representing a rate of 1.70 per 1,000 person-years, which was lower ...

GI perforation was reported in 9 and 3 patients, respectively. There was no statistical heterogeneity (p=0.532) considering all trials, so the fixed-effects model was used. Patients treated with ...

They say people using the drug are at higher risk of gastrointestinal perforation, especially if they have conditions that weaken the gastrointestinal wall, such as various types of GI cancers.