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HIF-1α+ macrophages were, in fact, highly abundant in sites of inflammation-associated intestinal fibrosis, but could not be found elsewhere in nearby regions of the intestine.

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: ...

"Effective degradation of scar tissue as a protective mechanism is mediated by TREM2, and the absence of TREM2+ macrophages not only disrupts the liver's ability to remove fibrotic tissue, but it ...

The team then dosed the diseased tissue with a drug called pirfenidone, which is a Food and Drug Administration-approved treatment that slows down the worsening of pulmonary fibrosis. Pirfenidone ...

Researchers initially compared macrophage activity in two models of disease, one that was known to follow a healthy repair path and one that resulted in fibrosis, over time to determine if there ...

Lipid-associated macrophages’ promotion of fibrosis resolution during MASH regression requires TREM2. Proceedings of the National Academy of Sciences, 2024; 121 (35) DOI: 10.1073/pnas.2405746121 ...

“MASH regression occurs in the presence if TREM2+ macrophages. They not only restrict the progression of MASH-fibrosis, but effectively slow it and reduce inflammation.

Notably, a single dose of macrophages expressing TIM4, alone or together with relaxin, significantly reduced liver fibrosis and hepatic stellate cell activation in the translationally relevant ...