A deficiency of β-galactosidase (pH 5.0) was found in frozen tissues (brain, liver, kidney and spleen) from 10 patients with Hurler's syndrome (Types 1–3). The diminished activity of this enzyme was ...
Certain glycans -- sugar-like compounds with carbohydrate chains -- containing galactose, may exhibit potential prebiotic properties that support human health. Identifying enzymes capable of breaking ...
- Preclinical studies support continued development of JAG101, an investigational gene therapy designed to address the root cause of Type 1 galactosemia and reduce multiple toxic metabolites - ...
Classic galactosemia is an autosomal recessive disorder caused by a deficiency of galactose-1-phosphate uridyltransferase (GALT EC 2.7.7.12). The biochemical phenotype is characterized by accumulation ...
9monon MSN
Novel enzyme breaks down and synthesizes previously unexplored glycans with prebiotic potential
Carbohydrate chains, or glycans, are complex sugar-like compounds that play important roles in various biological processes ...
A Denali Therapeutics drug for the rare enzyme deficiency Hunter syndrome is still in pivotal testing, but the company has guidance from the FDA on a pathway to get this therapy to the market sooner.
The enzyme discovered in the study, derived from the gut bacterium Bacteroides xylanisolvens, offers new opportunities for utilizing β-1,2-galactooligosaccharides with prebiotic properties and ...
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