Cyclic AMP (cyclic adenosine 3′,5′-monophosphate) is a second messenger and one of the most important intracellular mediators. Changes in intracellular cAMP levels correlate with GPCR activation.

References [1] Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription. Nature Communications (2023). [2] Epac-Inhibitors: Facts and Artefacts. Scientific Reports (2013).