The coronavirus disease 2019 (Covid-19) pandemic has highlighted the crucial role of randomized trials in guiding clinical practice and the need for designs that provide rapid evaluation of multiple ...

A fluoropyrimidine plus irinotecan or oxaliplatin, combined with bevacizumab (a monoclonal antibody against vascular endothelial growth factor), is standard first-line treatment for metastatic ...

Randomized controlled trials are the most reliable method available for testing new treatments. They have become the standard that pharmaceutical companies must meet for calculating and proving the ...