Cancer-associated fibroblasts (CAFs) create immune-dampening environments that help tumors grow, yet paradoxically, specific CAF subtypes can boost anti-tumor immunity. This review reveals how CAF ...

These include, among other things, the endogenous scavenger cells of the immune system, called macrophages, as well as types of cells that form connective tissue, such as fibroblasts.

In a paper published in Science Bulletin, the research team led by Professor Wen Zhang from the Department of Rheumatology and Immunology at Peking Union Medical College Hospital (PUMCH) has made ...

It demonstrates that macrophage-derived IFN-β stimulates the IFN-β-IFNAR-p-STAT1 axis in CFs, leading to the upregulation of chemokines (CCL2/7/12) that attract more macrophages.