In eukaryotes, the cell cycle consists of four discrete phases: G 1, S, G 2, and M. The S or synthesis phase is when DNA replication occurs, and the M or mitosis phase is when the cell actually ...

CID-078 is an orally bioavailable macrocycle with dual cyclin A and B RxL inhibitory activity that selectively targets tumor cells with oncogenic alterations that cause cell cycle dysregulation.

Circle Pharma is focusing its development efforts on cyclins, which are master regulators of the machinery that controls the progression of cells through the cell cycle and are key drivers in many ...

Circle Pharma is focusing its development efforts on cyclins, which are master regulators of the machinery that controls the progression of cells through the cell cycle and are key drivers in many ...

Circle Pharma is focusing its development efforts on cyclins, which are master regulators of the machinery that controls the progression of cells through the cell cycle and are key drivers in many ...

South San Francisco-based Circle Pharma, a clinical-stage biopharmaceutical company harnessing the power of macrocycles to develop therapies for cancer and other serious illnesses, announced that the ...

They applied a relatively new tool, the fluorescent ubiquitination-based cell-cycle indicator (FUCCI), to cultured mouse neurons to reveal those that re-engaged the cell cycle. At any given time, ...

To investigate the cell-cycle dependency of focal adhesion distribution and magnitude, Jones et al. investigated the role of cyclin‐dependent kinases (CDKs) in the regulation of adhesion dynamics.

These patterns of macromolecule production timing during the cell cycle are relevant contributions, said Nicolas Buchler, a biophysicist at the North Carolina State University who was not involved in ...

The articles in this Subject space focus on mechanisms that regulate the timing and frequency of DNA duplication and cell division. The study of the cell cycle has vast relevance to the health ...