Alpha-globin genes People have four alpha-globin genes located on chromosome 16. More than 130 possible changes to these genes are associated with alpha-thalassemia.

Sickle cell thalassemia usually refers more specifically to sickle beta-thalassemia. Both SCA and beta-thalassemia result from mutations in the gene that makes beta-globin, located on chromosome 11.

The delta globin gene sits upstream of the closely related beta globin gene in a gene cluster on chromosome 11. Attention turns to the delta globin gene on chromosome 11 as a potential key to ...

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of beta-globin. Gamma-globin combines with alpha-globin to form fetal hemoglobin.

But humans have another hemoglobin subunit gene (gamma-globin), which is expressed during fetal development instead of beta-globin. Gamma-globin combines with alpha-globin to form fetal hemoglobin.

Adult hemoglobin, expressed primarily after birth, contains four protein subunits—two beta-globin and two alpha-globin. Mutations in the beta-globin gene cause sickle cell disease and beta ...

In his approach, the beta-globin gene was transferred into the cells of two patients with beta-thalassamia. The experiment failed in part because the treated cells did not replicate. This incident led ...

Source: Hongeng S, et al. Abstract 1. Presented at: The 2021 TCT Meetings Digital Experience (virtual meeting); Feb. 8-12, 2021.

Researchers reported Friday that a preclinical study may have discovered a gene therapy vector candidate for blood disorders like sickle cell disease (SCD) and beta-thalassemia that could avoid ...

NEW ORLEANS —One-time treatment with the gene therapy betibeglogene autotemcel continued to demonstrate long-term efficacy among patients with transfusion-dependent beta-thalassemia, study ...

Mice harboring a human β S gene, instead of the mouse β-globin gene, have features of sickle cell disease, including anemia, microvasculature damage, and a shortened life span. 33-35 Erythroid ...