The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 mark heading into their matchup against Buffalo during the Week 13 NFL schedule.

The Colts are 4-1 against teams with a losing record. Our expert NFL predictions expect Jonathan Taylor to lead the Colts to victory.

We're already four games into the NFL Week 13 slate but we still have 11 games scheduled for today's slate. If you want to place a few bets on today's action,

SportsLine AI reveals the top Week 13 NFL prop picks for sites like PrizePicks, Underdog Fantasy, and Sleeper Fantasy

Get the latest Bo Nix odds, predictions, and picks ahead of Monday Night Football. Free NFL picks and predictions for December 1.

The Titans defense, which quietly has been one of the best in the NFL, should be able to take advantage. Tennessee ranks 11th in defensive DVOA and 8th in DVOA against the rush.

Our experts' predictions are in for Tennessee Titans vs. Washington Commanders. Here's who our experts are picking to win the Week 13 NFL game.

SportsLine's model simulated Tampa Bay Buccaneers vs. Carolina Panthers 10,000 times and made its Week 13 NFL picks, predictions and best bets

Dave Dameshek gives his full breakdown, best bets, game picks, and stats-backed predictions for the Week 13 NFL slate including PIT-CIN, PHI-BAL, and more.