The San Francisco 49ers were among the Super Bowl favorites heading into the season, but they find themselves below the .500 mark heading into their matchup against Buffalo during the Week 13 NFL schedule.

The Colts are 4-1 against teams with a losing record. Our expert NFL predictions expect Jonathan Taylor to lead the Colts to victory.

Here are our five best NFL Week 13 picks against the spread, including one over/under total to bet on this upcoming weekend.

Week 13 in the NFL is well underway with four games already under our belts over the Thanksgiving and Black Friday holiday. Now, it's time to heat up the leftovers and gear up for a jam-packed Sunday slate where we have a number of key matchups with major playoff implications.

Week 12 of the 2024-25 NFL season features seven divisional matchups, multiple games with double-digit point spreads and the first “Harbaugh Bowl” in over a dozen years.

After losing for the seventh time in eight games before the bye, the Jets (3-8) fired general manager Joe Douglas and rumors swirled about the future of QB Aaron Rodgers. If he ca