The type III secretion system (T3SS) is a sophisticated molecular apparatus that many Gram‐negative bacterial pathogens deploy to inject effector proteins directly into host cells. This ...

Secretion is gaining traction as a strategy for bacterial production, as it enables continuous fermentation and reduces purification costs. To engineer these systems to be competitive with production ...

With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells ...

T3 Pharmaceuticals has raised CHF 25 million ($27 million) to take its lead bacterial cancer therapy into the clinic. Boehringer Ingelheim Venture Fund (BIVF) co-led the round with the support of ...

Every secretion system in Y. entomophaga was knocked out until no more were left, yet the bacteria were still able to secrete YenTc. The researchers then used fluorescence microscopy to observe ...

Cryo-EM structure of a type IV secretion system. Nature, 2022; 607 (7917): 191 DOI: 10.1038/s41586-022-04859-y ...

Bacteria use molecular machines to move proteins, including toxins, across cell membranes. M. tuberculosis, which kills more than 1 million people a year, uses the ESX-4 type VII secretion system to ...

Superinfections can occur in both influenza and COVID-19, and the investigators caution that type III interferons given later in the course of COVID-19 could do more harm than good.