“Our proposed biological mechanism for the association between PPIs and MACE is more consistent with the available human data than previously proposed drug-drug interactions,” the authors contend, ...

Part 1: mechanisms and clinical measurements In the first section of this two-part Review, Dr Sweeny and colleagues explore the phenomenon of 'resistance' to antiplatelet drug therapy.

Long-term overtreatment with the anti-clotting drug warfarin combined with antiplatelet therapy to prevent stroke may raise the risk of dementia in people with atrial fibrillation, researchers ...

Thus, clopidogrel provides its antiplatelet effect via selective and irreversible inhibition of ADP-induced platelet aggregation mediated by the P2Y 12 receptor, a mechanism of action distinct ...

Currently, there are many antiplatelet drugs available in clinical practice, both in oral and parenteral dosage forms. Aspirin, the inhibitor of COX-1, was the first antiplatelet compound used in ...

Many people develop chronic kidney disease (CKD) as they grow older, and many people with CKD take antiplatelet agents to prevent cardiovascular events. However, the efficacy of antiplatelet ...

Single antiplatelet therapy was tied to lower 6-month mortality risk vs. dual antiplatelet therapy after transcatheter aortic valve replacement. The results were consistent by sex and presence of CAD.

1. Mohammad RA, Goldberg T, Dorsch MP, Cheng JW. Antiplatelet therapy after placement of a drug-eluting stent: a review of efficacy and safety studies. Clin Ther. 2010;32 (14):2265-2281. 2.

Key takeaways: The multitarget stool DNA test had a positive predictive value of 31.4% for detecting advanced adenomas. Patients on oral anticoagulants or antiplatelet agents showed no meaningful ...

Meeting Coverage > EuroPCR Step-Down Antiplatelet Strategy Pairs Well With DCB Angioplasty — REC-CAGEFREE II is the first randomized trial on antiplatelet strategies after DCB therapy by Nicole ...

Like all antiplatelet therapies, it does create some challenges for patients with serious bleeding events or who need urgent surgery,” said John Lee, M.D., Ph.D., Chief Medical Officer of PhaseBio.

Low-profile, coated stent with potential applications that could allow patients to avoid complications of dual antiplatelet therapy December 14, 2023 08:00 AM Eastern Standard Time ...