The FDA's approval of the first CRISPR-Cas9–based gene therapy marked a major milestone in biomedicine, validating genome ...

Anthrax toxin receptor (ATR), as it was named, is a protein with 368 amino acids, or units, in a chain. A stretch of it resembles some other cellular receptors in the body, but its normal function ...

Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of ...

"We have changed the anthrax toxin so that it's only activated and toxic once it's in contact with the surface of the cancer cell," says Thomas Bugga, research scientist at the National Institutes ...

When exposed to lethal toxin or B. anthracis, mice with either modified MEK1/2 or MEK3/6 had much greater survival than normal animals, indicating that anthrax must inactivate both the ERK and p38 ...

When the scientists downregulated the genes of TMED2 and TMED10, the anthrax toxin lost its ability to form pores. Further, in-depth analysis uncovered something new in terms of basic cell biology ...

The disease was caused by bacteria within the B. cereus group that produces anthrax toxin; these bacteria thrive in lungs affected by welding fumes and iron deposits.

Oedema factor (EF) — a calmodulin-activated adenylyl cyclase — is important in the pathogenesis of anthrax, but the relationship between the structure of EF and its function remains unclear. In ...

Anthrax toxin, which due to unfortunate circumstances has become a topic of great public interest at the moment, has three parts: lethal factor (LF), oedema factor (OF) and the protective agent (PA).

The anthrax grant “is critical for me because I’m just becoming independent,” she says. “And also, working in a hospital system, we are working on soft money, which means I have to get my ...

Robert Siegel talks with Graham Richards, chemistry department chairman at Oxford University, about research under way to find cure for anthrax. Richards is leading the effort. He wants to get at ...