In a small study, researchers have discovered how a set of genes could cause neurons to die in sporadic ... type of motor neuron, that express the marker THY1. In people with ALS, this was linked ...

Of the 91 patients originally diagnosed with PMA, 20 subsequently developed upper motor neuron signs, which would qualify them as having ALS with lower motor neuron onset. Furthermore, upper motor ...

Approximately 5,000 people in the U.S. develop amyotrophic lateral sclerosis (ALS) each year. On average, they survive for ...

People with ALS – the most common form of motor neuron disease – experience problems with walking, speaking, swallowing and ...

Microscopy image of a brain organoid showing neuron precursors (magenta) and deep-layer projection neurons (green), which are one of the cell types affected by autism risk gene mutations.

However, the outcome and end product of these mutations is a motor neuron disease ... exact mechanism of ALS. That’s why proving causation is very hard.” About 90% of ALS cases occur without family ...

Sweatshirts, hot drinks, you name it. When you think of ALS, you think despair, decay, doom. But if you follow Eby on social media like TikTok and Instagram, you're likely fighting off fits of ...

Diagnosed with amyotrophic lateral sclerosis (ALS), the disease not only affected Kerner's mobility but also her ability to speak. However, thanks to artificial intelligence technology ...

In this CREST project we will develop animal models mimicking molecular events observed in the pathological tissues of sporadic ALS patients and clarify molecular pathogenesis and target mol-ecules ...

and motor neurone disease (MND) symposia this fall. "These important meetings bring together the leading ALS researchers, clinicians, care providers, drug developers, and industry partners from ...

Progressive muscular atrophy (PMA) is clinically characterized solely by signs of lower motor neuron dysfunction, so patients with this condition are commonly excluded from ALS clinical trials.

The findings could lead to development of therapies to prevent or slow the progression of ALS early on, before major damage has been done. The study was published on October 31, 2024 in Neuron.