The words “addiction,” “tolerance,” and “physical dependence” are often used interchangeably when it comes to drug or alcohol use. But they don’t mean the same thing.

Many people use the terms “tolerance,” “resistance,” “dependence,” and “addiction” interchangeably. However, they are unique terms describing different conditions.

The terms “addiction” and “dependence” can seem similar, but they are different. Dependence occurs when the body physically relies on a drug. Addiction involves changes in behavior.

If the same exists in humans, treatments that inhibit it could prevent opioid addiction By Grace Wade 8 February 2023 The context in which opioids are taken can impact tolerance for their effects ...