The findings of this study indicate that 5-HT signaling plays a key role in excitatory synapse maturation during early development of the PFC circuits, regulating spine maturation and function.

Scientists have uncovered how the brain’s 5-HT1A serotonin receptor—vital in mood regulation—functions at the molecular level.

In addition to 5-HT 1A and 5-HT 1B autoreceptor desensitization, chronic SSRI treatment in adults has frequently been associated with desensitization and/or downregulation of other receptor ...

“It is thus conceivable that intestinal epithelial 5-HT signaling impacts gut-brain communication and ultimately mood,” the team pointed out.

The researchers used a series of assays to measure the effect that seven different SNPs had on in vitro binding and signaling of the 5-HT 2A serotonin receptor when in the presence of psilocin ...