The San Francisco 49ers will be without their top two running backs for the remainder of the regular season after the pair of rushers suffered injuries on Sunday Night Football against the Buffalo Bills.

The San Francisco 49ers expect to get quarterback Brock Purdy back for their Week 13 matchup with the Buffalo Bills. That’s where the good injury news ends for San Francisco. Head coach Kyle Shanahan on Friday after practice told reporters Purdy was a full

On Saturday night, ESPN's Adam Schefter reported that San Francisco 49ers quarterback Brock Purdy, officially listed as questionable, is expected to start Sunday night against the Buffalo Bills.

See what Kyle Shanahan, Brock Purdy, Sean McDermott and Josh Allen had to say following the Week 13 primetime contest.

We're live with the Week 13 edition of "Sunday Night Football" as the Buffalo Bills play host to the San Francisco 49ers to cap what has been a wild Thanksgiving weekend of NFL games. San Francisco enters this game incredibly banged up,

It was December football Sunday night in Buffalo. Playing in below-freezing temperatures and in the snow, the Buffalo Bills (10-2) defeated the San Francisco 49ers (5-7), 35-10, at Highmark Stadium. The 49ers took an early 3-0 lead in the first quarter,