McDonald County is a county located in the southwestern corner of the U.S. state of Missouri. As of the 2020 census, the population was 23,303. Its county seat is Pineville. The county was organized in 1849 and named for Sergeant Alexander McDonald, a soldier in the American Revolutionary War. The county has three sites on the National Register of Historic …McDonald County is a county located in the southwestern corner of the U.S. state of Missouri. As of the 2020 census, the population was 23,303. Its county seat is Pineville. The county was organized in 1849 and named for Sergeant Alexander McDonald, a soldier in the American Revolutionary War. The county has three sites on the National Register of Historic Places, including the Old McDonald County Courthouse and the Powell Bridge.
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