Ketamine - Wikipedia
WEBIts distinguishing features as anesthesia are preserved breathing and airway reflexes, stimulated heart function with increased blood pressure, and moderate bronchodilation. [21] At lower, sub-anesthetic doses, it is a promising agent for treatment of pain and treatment-resistant depression. [22]
Ketamine | C13H16ClNO | CID 3821 - PubChem
WEBKetamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system.
Ketamine Pharmacology: An Update (Pharmacodynamics and …
WEBApr 10, 2013 · The NMDA receptor, blocked by ketamine for concentrations between 2 and 50 μ m, is responsible for ketamine's most important pharmacological properties. Glutamate is the most prevalent amino acid in the central nervous system (CNS), involving glutaminergic synapses.
Ketamine: Uses, Interactions, Mechanism of Action - DrugBank …
WEBKetamine is a rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Brand Names
Ketamine as an antidepressant: overview of its mechanisms of …
WEBMay 11, 2020 · Antidepressant mechanisms of ketamine and potential biochemical biomarkers. Glutamate is the main excitatory neurotransmitter in the central nervous system, acting on NMDA and -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) ionotropic receptors, as well as metabotropic glutamate receptors.
WEBKetamine is a dissociative anesthetic that has some hallucinogenic effects. It distorts perceptions of sight and sound and makes the user feel disconnected and not in control. It is an injectable, short-acting anesthetic for use in humans and animals. It is referred to as a “dissociative anesthetic” because it makes patients feel detached ...
Ketamine - StatPearls - NCBI Bookshelf
WEBJan 30, 2024 · Indications. Ketamine hydrochloride, commonly known as ketamine, is a medication approved by the United States Food and Drug Administration (FDA) for use as a general anesthetic either on its own or in combination with other medications. FDA-Approved Indications.
Ketamine • LITFL • CCC Pharmacology
WEBKetamine: phencyclidine derivative hypnotic and analgesic. NMDA receptor antagonist resulting in dissociative anaesthesia (profound analgesia with superficial sleep); interacts with opioid receptors - mu, delta and kappa.
Ketamine: A Review of Clinical Pharmacokinetics and ... - PubMed
WEBKetamine produces hemodynamically stable anesthesia via central sympathetic stimulation without affecting respiratory function. Animal studies have shown that ketamine has neuroprotective properties, and there is no evidence of elevated intracranial pressure after ketamine dosing in humans.
Ketamine: Uses, Dosage, Side Effects, Warnings - Drugs.com
WEBAug 27, 2024 · It is also a drug of abuse that is used illegally recreationally for its hallucinogenic properties and is known to be a “date rape” drug as it causes short-term memory loss. Ketamine is not an opioid (narcotic); it is an NMDA receptor antagonist, which means it blocks the N-methyl-D-aspartate (NMDA) neurotransmitter in the brain.
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